Skeletal muscle tissue growth

Across TCGA patient cohorts, RNA activity of the Skeletal muscle tissue growth pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FUT11, MTM1, and VCL_S795, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle tissue growth activity versus FUT11 in UCEC (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FUT11 →	-0.336	-0.092	.001	.002	3	6
OV	MTM1 →	+0.283	+0.103	<.001	<.001	3	6
BRCA	VCL_S795 →	-0.369	-0.046	<.001	.003	3	6
UCEC	DPYSL3_S522 →	-0.649	-0.103	.007	.001	3	5
GBM	IKBIP →	-0.545	-0.139	.003	<.001	3	5
BRCA	ITGA11 →	-0.675	-0.067	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048630 vs FUT11 — UCEC

Explore this scatter interactively →