Skeletal muscle tissue growth

Across TCGA pan-cancer cohorts, RNA activity of the Skeletal muscle tissue growth pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Skeletal muscle tissue growth pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and STAD, show the opposite pattern, with higher activity associated with better survival.

LIHC, OV, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.375	0.219	<.001	76	view →
OV	OS	Tertile	IV	0.251	0.525	.004	48	view →
STAD	DFS	Median	IV	0.708	0.187	.004	30	view →
SCLC	OS	Tertile	III,IV	0.825	0.395	.002	30	view →
MESO	OS	Quartile	III,IV	0.254	0.516	.018	24	view →
KIRC	DFS	Quartile	All	0.873	0.672	.004	19	view →
GBM	OS	Median	All	0.500	0.324	.003	18	view →
UCS	DFS	Quartile	II,III,IV	0.690	0.169	.009	18	view →
ACC	DFS	Median	IV	0.163	0.528	.003	13	view →
KIRP	DFS	Median	All	0.606	0.895	.006	10	view →
HNSC	DFS	Median	All	0.216	0.455	.005	10	view →
CHOL	OS	Median	IV	0.136	0.829	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0048630–LIHC (DFS)

Open the LIHC breakdown →