Skeletal muscle tissue growth

Across TCGA cell cohorts, RNA activity of the Skeletal muscle tissue growth pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5AR1, ZNF692, and PILRB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C5AR1 grouped by Skeletal muscle tissue growth-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	C5AR1 →	-1.242	-1.920	.001	<.001	3	4
BLOOD_Leukemia	ZNF692 →	-0.623	-1.324	.008	.006	3	4
PANCREAS	PILRB →	-1.201	-1.748	.001	<.001	3	4
KIDNEY	THBS3 →	-2.123	-0.648	.004	.001	3	4
CNS	CDK8 →	+0.785	+1.247	.002	<.001	3	4
BONE	SLC2A1 →	-1.492	-1.424	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C5AR1 by Skeletal muscle tissue growth activity — PANCREAS

Explore this box plot interactively →