Embryonic camera-type eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic camera-type eye morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PEAK1, SYDE1, and ADD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic camera-type eye morphogenesis activity versus PEAK1 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PEAK1 →	+0.295	+0.047	<.001	<.001	3	6
BRCA	SYDE1 →	+0.211	+0.026	.002	<.001	3	5
LUAD	ADD3 →	+0.296	+0.047	<.001	.002	3	5
HNSC	UPP1 →	-0.688	-0.054	.003	.001	2	6
OV	DAPK3 →	+0.515	+0.067	<.001	<.001	3	5
OV	FKBP7 →	+0.619	+0.077	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048596 vs PEAK1 — BRCA

Explore this scatter interactively →