Embryonic camera-type eye morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic camera-type eye morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SECTM1, IL27, and SLAMF8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic camera-type eye morphogenesis activity versus SECTM1 in HNSC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SECTM1 →	-0.830	-0.210	.006	.007	3	5
BRCA	IL27 →	-0.382	-0.109	.004	.009	3	5
CCRCC	SLAMF8 →	-0.544	-0.168	.006	.002	3	5
UCEC	MAP3K12 →	+0.418	+0.207	<.001	<.001	3	5
GBM	CORO1A →	-0.627	-0.297	.001	.001	3	4
GBM	CD86 →	-0.653	-0.237	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048596 vs SECTM1 — HNSC

Explore this scatter interactively →