Embryonic digestive tract development

Across TCGA patient cohorts, RNA activity of the Embryonic digestive tract development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSL1, ZNF740, and ZNF43, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic digestive tract development activity versus NSL1 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NSL1 →	+0.360	+0.711	.001	<.001	3	5
BRCA	ZNF740 →	+0.465	+0.740	.001	<.001	3	5
GBM	ZNF43 →	+0.556	+0.678	.002	.002	3	5
LUAD	ZNF345 →	+0.398	+0.518	<.001	<.001	3	5
BRCA	IQCH-AS1 →	+0.382	+0.659	<.001	<.001	3	5
BRCA	RCOR3 →	+0.530	+0.563	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048566 vs NSL1 — BRCA

Explore this scatter interactively →