Embryonic digestive tract development

Across TCGA cell cohorts, RNA activity of the Embryonic digestive tract development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCAN1, NRP1, and MICOS13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCAN1 grouped by Embryonic digestive tract development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RCAN1 →	-1.391	-0.892	.002	.007	3	4
SOFT_TISSUE	NRP1 →	-2.870	-0.994	<.001	.002	3	4
BLOOD_Myeloma	MICOS13 →	-0.805	-1.138	.001	.001	3	3
BLOOD_Myeloma	C6orf89 →	-0.793	-1.387	<.001	.002	3	3
OVARY	CMTM4 →	+0.822	+0.758	.005	.003	3	3
PANCREAS	PBLD →	-1.191	-1.198	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCAN1 by Embryonic digestive tract development activity — SKIN

Explore this box plot interactively →