Embryonic digestive tract development

Across TCGA cell cohorts, RNA activity of the Embryonic digestive tract development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGT1, TENT5B, and ERAP2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic digestive tract development activity versus GGT1 in CNS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GGT1 →	-2.036	-1.566	.007	.002	3	2
CNS	TENT5B →	+1.862	+1.564	.009	.006	3	2
CNS	ERAP2 →	-2.325	-1.095	.002	.002	3	2
CNS	FAM220A →	-0.769	-1.719	.002	.007	3	2
CNS	SLC25A1 →	+0.840	+1.440	.003	.006	3	1
CNS	SOS2 →	-0.845	-1.159	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048566 vs GGT1 — CNS

Explore this scatter interactively →