Embryonic digestive tract development

Across TCGA cell cohorts, RNA activity of the Embryonic digestive tract development pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM162A, MPHOSPH10, and MED1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic digestive tract development activity versus FAM162A in BONE (Pearson r = -0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FAM162A →	-0.915	-0.484	<.001	.008	3	1
BONE	MPHOSPH10 →	+1.020	+0.656	.007	.007	3	1
BONE	MED1 →	-0.419	-0.484	.005	.008	3	1
BONE	SND1 →	-1.373	-0.689	.008	.008	2	2
BONE	AQR →	+0.929	+0.484	<.001	.008	3	1
BONE	SFSWAP →	-0.766	-0.689	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048566 vs FAM162A — BONE

Explore this scatter interactively →