Embryonic digestive tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic digestive tract morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FES_T421, PPP1R18, and PTPN6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic digestive tract morphogenesis activity versus FES_T421 in COAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FES_T421 →	-0.531	-0.063	<.001	<.001	3	6
COAD	PPP1R18 →	-0.407	-0.051	<.001	<.001	3	6
LSCC	PTPN6 →	-0.261	-0.057	<.001	<.001	3	6
LSCC	STARD3NL_S39 →	-1.114	-0.091	.001	.002	3	5
COAD	CTHRC1 →	-0.941	-0.054	<.001	<.001	3	5
OV	FKBP15 →	-0.206	-0.048	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048557 vs FES_T421 — COAD

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