Embryonic digestive tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic digestive tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PI4K2B, SLC30A9, and PTPRU, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PI4K2B grouped by Embryonic digestive tract morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PI4K2B →	-0.716	-0.996	.001	.004	2	6
BLOOD_Myeloma	SLC30A9 →	-1.380	-1.508	<.001	.001	3	4
KIDNEY	PTPRU →	+2.088	+1.294	.003	<.001	3	4
BONE	TCEA3 →	+3.433	+1.132	.002	.003	3	4
CNS	CCNB1IP1 →	+0.856	+1.138	.002	<.001	3	4
LARGE_INTESTINE	E2F6 →	+0.552	+0.985	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PI4K2B by Embryonic digestive tract morphogenesis activity — CNS

Explore this box plot interactively →