Embryonic digestive tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic digestive tract morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM2, SPTLC1, and UGGT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LSM2 grouped by Embryonic digestive tract morphogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LSM2 →	-0.318	-0.328	.002	.001	3	4
BLOOD_Myeloma	SPTLC1 →	+0.256	+0.256	<.001	<.001	3	3
BLOOD_Myeloma	UGGT2 →	+0.255	+0.269	.003	.003	2	4
BLOOD_Myeloma	ACTG1 →	+0.475	+0.331	<.001	<.001	3	3
BLOOD_Lymphoma	RABL2A →	-0.287	-0.229	.007	.003	3	3
BLOOD_Lymphoma	VAX1 →	-0.147	-0.271	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LSM2 by Embryonic digestive tract morphogenesis activity — SOFT_TISSUE

Explore this box plot interactively →