Positive regulation of pinocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of pinocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISLR, SLIRP, and YME1L1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pinocytosis activity versus ISLR in CCRCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ISLR →	+0.621	+0.040	.001	<.001	3	9
LSCC	SLIRP →	-0.385	-0.056	<.001	<.001	3	8
UCEC	YME1L1 →	-0.425	-0.071	<.001	.002	3	8
UCEC	ZCCHC24 →	+0.611	+0.071	<.001	<.001	3	8
OV	LRPPRC →	-0.457	-0.075	<.001	.002	3	8
LSCC	MRPL3 →	-0.351	-0.060	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048549 vs ISLR — CCRCC

Explore this scatter interactively →