Positive regulation of pinocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of pinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCF2L, SYNPO, and HMGB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCF2L grouped by Positive regulation of pinocytosis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MCF2L →	-3.250	-1.317	.001	.003	3	5
OVARY	SYNPO →	+2.208	+0.997	<.001	.001	3	5
OVARY	HMGB1 →	-0.657	-1.057	.001	.001	3	5
PANCREAS	RRAGC →	+0.790	+1.826	<.001	<.001	3	5
LUNG_NSCLC_LUAD	GADD45B →	+1.153	+1.251	<.001	<.001	3	4
LUNG_SCLC	MARCKSL1 →	-1.781	-1.523	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCF2L by Positive regulation of pinocytosis activity — LUNG_SCLC

Explore this box plot interactively →