Positive regulation of pinocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of pinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPT1, C1QBP, and DNAH17, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pinocytosis activity versus PPT1 in LUNG_SCLC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPT1 →	+2.528	+0.293	<.001	<.001	3	10
BLOOD_Myeloma	C1QBP →	-1.329	-0.176	<.001	<.001	3	8
BONE	DNAH17 →	+0.524	+0.439	.003	<.001	3	7
OVARY	ITGA2B →	+0.903	+0.344	.007	.005	3	6
BLOOD_Lymphoma	GPR156 →	+0.076	+0.151	.008	.002	3	6
PANCREAS	TCF7 →	-2.088	-0.475	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048549 vs PPT1 — LUNG_SCLC

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