Regulation of pinocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of pinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGD2, CXorf21, and CCR2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pinocytosis activity versus FGD2 in SKCM (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FGD2 →	+1.062	+0.055	<.001	<.001	3	32
SKCM	CXorf21 →	+1.155	+0.058	<.001	<.001	3	31
DLBC	CCR2 →	+1.410	+0.075	<.001	.001	2	32
SKCM	RGS18 →	+0.867	+0.056	<.001	<.001	3	31
SCLC	GIMAP5 →	+1.709	+0.151	<.001	<.001	3	31
CHOL	CSF2RB →	+1.837	+0.096	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048548 vs FGD2 — SKCM

Explore this scatter interactively →