Regulation of pinocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of pinocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL_S246, CLPX, and C1QA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pinocytosis activity versus EVL_S246 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EVL_S246 →	+0.647	+0.072	.001	.004	3	7
LSCC	CLPX →	-0.270	-0.067	<.001	<.001	3	7
GBM	C1QA →	+0.574	+0.064	<.001	<.001	3	6
HNSC	ESF1_S198 →	-0.475	-0.069	.001	.003	3	6
LSCC	ARHGAP31_S954 →	+0.733	+0.087	<.001	<.001	3	6
GBM	SEPTIN1_S206 →	+1.055	+0.083	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048548 vs EVL_S246 — UCEC

Explore this scatter interactively →