Regulation of pinocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of pinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAD2L1, KPNA2, and BIRC5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pinocytosis activity versus MAD2L1 in BRCA (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAD2L1 →	-0.829	-0.194	<.001	<.001	2	6
BRCA	KPNA2 →	-0.878	-0.172	<.001	.001	3	5
BRCA	BIRC5 →	-1.253	-0.214	<.001	<.001	3	5
BRCA	ADGRL4 →	+0.534	+0.157	<.001	<.001	3	5
LSCC	LINC01480 →	+0.590	+0.085	.003	.001	3	5
LSCC	FANCE →	-0.809	-0.111	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048548 vs MAD2L1 — BRCA

Explore this scatter interactively →