Regulation of pinocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of pinocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS1, CAVIN1_S175, and MFAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pinocytosis activity versus TNS1 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS1 →	+0.596	+0.278	<.001	<.001	3	5
BRCA	CAVIN1_S175 →	+1.232	+0.252	<.001	<.001	3	5
BRCA	MFAP4 →	+1.228	+0.157	<.001	.001	3	5
BRCA	MYH11 →	+0.969	+0.193	<.001	<.001	3	5
BRCA	SORBS3 →	+0.256	+0.166	<.001	<.001	3	4
BRCA	TLN2 →	+0.455	+0.140	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048548 vs TNS1 — BRCA

Explore this scatter interactively →