Regulation of pinocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of pinocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42, PPT1, and WDR49, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC42 grouped by Regulation of pinocytosis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CDC42 →	-0.599	-2.062	.003	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	PPT1 →	-0.279	-1.010	<.001	.002	3	10
SKIN	WDR49 →	+0.159	+0.599	<.001	.001	3	4
LUNG_SCLC	TAF1B →	-0.193	-1.004	<.001	.001	3	4
OVARY	CD207 →	-0.149	-0.607	.003	.005	3	4
URINARY_TRACT	DDIT4 →	-0.357	-1.739	.004	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC42 by Regulation of pinocytosis activity — BLOOD_Lymphoma

Explore this box plot interactively →