Regulation of pinocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of pinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP251, DLK2, and BBS9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pinocytosis activity versus CFAP251 in OESOPHAGUS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CFAP251 →	+2.325	+0.393	<.001	<.001	3	6
STOMACH	DLK2 →	+1.727	+0.352	.003	.001	3	6
OVARY	BBS9 →	+1.121	+0.327	<.001	.003	3	5
LUNG_SCLC	PPT1 →	+2.036	+0.276	<.001	<.001	3	5
SKIN	CLUH →	-0.997	-0.276	<.001	.001	3	5
LIVER	BCAR3 →	+3.140	+0.570	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048548 vs CFAP251 — OESOPHAGUS

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