Digestive tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Digestive tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GADD45GIP1, TSPAN15, and PHC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestive tract morphogenesis activity versus GADD45GIP1 in URINARY_TRACT (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GADD45GIP1 →	-1.155	-2.214	.003	.002	2	5
LUNG_NSCLC_LUAD	TSPAN15 →	+1.443	+1.078	.003	.001	3	4
CNS	PHC1 →	-0.884	-1.771	<.001	<.001	3	4
CNS	FAAP20 →	-0.543	-1.514	.004	<.001	3	4
LUNG_NSCLC_LUAD	DUSP4 →	+2.983	+1.341	<.001	.001	3	4
LUNG_NSCLC_LUAD	MRAS →	-1.825	-1.148	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048546 vs GADD45GIP1 — URINARY_TRACT

Explore this scatter interactively →