Spleen development

Across TCGA cell cohorts, RNA activity of the Spleen development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSE1L, PRIM1, and CDK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spleen development activity versus CSE1L in LARGE_INTESTINE (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSE1L →	-0.868	-1.908	.002	<.001	3	5
BLOOD_Leukemia	PRIM1 →	-0.466	-0.385	.002	.001	3	5
STOMACH	CDK2 →	-0.997	-1.816	<.001	<.001	3	4
STOMACH	SENP1 →	-1.100	-1.947	.004	.001	3	4
BLOOD_Leukemia	SNTB2 →	-1.409	-0.321	<.001	.003	3	4
BLOOD_Leukemia	NUP205 →	-0.630	-0.299	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048536 vs CSE1L — LARGE_INTESTINE

Explore this scatter interactively →