Lymph node development

Across TCGA cell cohorts, RNA activity of the Lymph node development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCE1, TUBA1A, and CPLANE2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCE1 grouped by Lymph node development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLCE1 →	+1.024	+1.390	.001	.001	3	4
BREAST	TUBA1A →	-3.015	-1.068	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CPLANE2 →	-0.702	-0.654	.001	<.001	3	3
LUNG_NSCLC_LUAD	FBRS →	-0.622	-0.709	.008	.004	2	4
BLOOD_Leukemia	RDH10 →	+1.648	+0.893	.001	.002	3	3
BLOOD_Myeloma	ZNF205 →	+1.552	+1.112	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCE1 by Lymph node development activity — LUNG_SCLC

Explore this box plot interactively →