Negative regulation of viral process

Across TCGA cell cohorts, RNA activity of the Negative regulation of viral process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPLL, RPS6KA1, and FAM171B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral process activity versus HNRNPLL in BLOOD_Lymphoma (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HNRNPLL →	+2.456	+0.196	.003	.006	3	6
LUNG_NSCLC_LUAD	RPS6KA1 →	+0.937	+0.189	<.001	<.001	3	4
SOFT_TISSUE	FAM171B →	+1.724	+0.233	.006	.005	2	5
BLOOD_Lymphoma	GCH1 →	+1.406	+0.209	.001	<.001	3	4
BLOOD_Lymphoma	CCDC194 →	+1.430	+0.192	.002	.004	2	5
BLOOD_Myeloma	GATD3A →	+1.926	+0.146	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048525 vs HNRNPLL — BLOOD_Lymphoma

Explore this scatter interactively →