Spermatid differentiation

Across TCGA patient cohorts, RNA activity of the Spermatid differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOD2, UPP1, and TNFRSF14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermatid differentiation activity versus NOD2 in GBM (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NOD2 →	-0.988	-0.165	.001	.002	3	4
HNSC	UPP1 →	-0.901	-0.171	.003	.001	3	4
CCRCC	TNFRSF14 →	-0.402	-0.697	.003	.002	3	4
GBM	RNU6-647P →	+1.066	+0.149	<.001	.001	3	4
BRCA	TNNI2 →	-0.694	-0.203	.003	<.001	3	4
GBM	ESCO2 →	+0.921	+0.158	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048515 vs NOD2 — GBM

Explore this scatter interactively →