Synaptic vesicle membrane organization

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK7, PTPRN2, and SYNCRIP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle membrane organization activity versus PTK7 in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PTK7 →	-0.500	-0.227	<.001	<.001	3	6
BRCA	PTPRN2 →	+1.071	+0.180	.007	.005	3	4
OV	SYNCRIP →	-0.389	-0.157	.001	.008	3	4
OV	RARS2 →	-0.444	-0.204	.001	.002	3	4
LSCC	ZNF473 →	-0.287	-0.122	.002	.002	3	4
LSCC	CELF1 →	-0.251	-0.120	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048499 vs PTK7 — PDAC

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