Synaptic vesicle membrane organization

Across TCGA pan-cancer cohorts, RNA activity of the Synaptic vesicle membrane organization pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 28 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Synaptic vesicle membrane organization pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PAAD and SARC, show the opposite pattern, with higher activity associated with better survival.

PAAD, ESCA, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Quartile	All	0.614	0.274	.002	47	view →
ESCA	OS	Median	IV	0.143	0.650	.004	33	view →
BLCA	DFS	Quartile	III,IV	0.147	0.560	<.001	29	view →
STAD	DFS	Median	All	0.622	0.766	.024	26	view →
UVM	DFS	Tertile	III,IV	0.475	1.000	.009	23	view →
CESC	DFS	Median	All	0.447	0.615	.016	18	view →
MESO	DFS	Median	All	0.272	0.414	.009	17	view →
LUAD	OS	Tertile	II,III,IV	0.461	0.628	.004	15	view →
SARC	OS	Median	All	0.908	0.783	.001	15	view →
THYM	OS	Quartile	II,III,IV	0.819	1.000	.009	14	view →
LIHC	DFS	Tertile	All	0.425	0.605	.004	13	view →
COAD	DFS	Tertile	IV	0.226	0.567	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0048499–PAAD (OS)

Open the PAAD breakdown →