Synaptic vesicle membrane organization

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle membrane organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OC90, AGBL3, and DYNC2H1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OC90 grouped by Synaptic vesicle membrane organization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OC90 →	-0.283	-1.451	<.001	.002	2	9
BLOOD_Myeloma	AGBL3 →	-0.860	-2.290	.002	<.001	2	8
LARGE_INTESTINE	DYNC2H1 →	-0.391	-1.403	.001	.009	3	6
URINARY_TRACT	SNAP23 →	-0.445	-1.887	.002	<.001	3	6
BLOOD_Myeloma	MLC1 →	-0.750	-2.170	.002	.001	1	8
CNS	NPTN →	-0.312	-1.358	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OC90 by Synaptic vesicle membrane organization activity — LARGE_INTESTINE

Explore this box plot interactively →