Synaptic vesicle membrane organization

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMTC2, RIPOR1, and PCNX4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMTC2 grouped by Synaptic vesicle membrane organization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMTC2 →	+1.613	+1.474	.001	.001	3	4
OESOPHAGUS	RIPOR1 →	-1.220	-1.082	.001	.002	3	4
LUNG_NSCLC_LUSC	PCNX4 →	-1.198	-1.524	.001	.001	3	4
BLOOD_Leukemia	PHLDA2 →	-2.384	-1.713	<.001	.002	3	4
URINARY_TRACT	CHURC1 →	-0.625	-1.474	.009	.001	3	4
KIDNEY	JPH2 →	-2.388	-1.716	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMTC2 by Synaptic vesicle membrane organization activity — URINARY_TRACT

Explore this box plot interactively →