Negative regulation of retinoic acid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of retinoic acid receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM2, MCM3, and MCM4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of retinoic acid receptor signaling pathway activity versus MCM2 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM2 →	+0.624	+0.094	<.001	<.001	3	8
GBM	MCM3 →	+0.725	+0.119	<.001	<.001	3	8
GBM	MCM4 →	+0.696	+0.095	<.001	<.001	3	8
GBM	MCM5 →	+0.716	+0.108	<.001	<.001	3	8
GBM	MCM6 →	+0.779	+0.103	<.001	<.001	3	8
GBM	MCM7 →	+0.598	+0.088	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048387 vs MCM2 — GBM

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