Regulation of retinoic acid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of retinoic acid receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, RAB31_T38, and SVIL_S769, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of retinoic acid receptor signaling pathway activity versus AKR1C3 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C3 →	+0.884	+0.060	<.001	.003	3	4
BRCA	RAB31_T38 →	-0.711	-0.030	<.001	.005	3	4
COAD	SVIL_S769 →	+0.470	+0.026	.007	.003	3	4
COAD	SYNPO2_S820 →	+1.036	+0.046	<.001	<.001	3	4
LSCC	NHLRC2 →	+0.154	+0.050	.002	.001	3	4
LUAD	OSBP_S351 →	-0.433	-0.061	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048385 vs AKR1C3 — UCEC

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