Regulation of retinoic acid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of retinoic acid receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EZH2, MIS18BP1_T653, and THRAP3_S232, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of retinoic acid receptor signaling pathway activity versus EZH2 in HNSC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EZH2 →	+0.516	+0.891	<.001	<.001	3	4
LSCC	MIS18BP1_T653 →	+0.984	+0.696	<.001	<.001	3	4
LSCC	THRAP3_S232 →	+0.536	+0.233	.006	<.001	2	4
UCEC	TAB1_S7 →	-0.837	-0.254	.003	.001	3	3
LSCC	TOP2A_S1247 →	+1.155	+0.573	<.001	<.001	3	3
LSCC	KMT2E_S1359 →	-0.776	-1.818	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048385 vs EZH2 — HNSC

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