Retinoic acid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Retinoic acid receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCLAF1_S177, MAPK3, and SPC25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinoic acid receptor signaling pathway activity versus BCLAF1_S177 in GBM (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCLAF1_S177 →	-0.267	-0.040	.001	<.001	3	5
UCEC	MAPK3 →	+0.272	+0.061	<.001	<.001	3	5
GBM	SPC25 →	-0.517	-0.044	.001	<.001	3	4
COAD	LUM →	+0.642	+0.029	.002	.001	3	4
GBM	SPC24 →	-0.448	-0.026	.001	.001	3	4
GBM	SVIL_S914 →	+1.012	+0.041	.002	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048384 vs BCLAF1_S177 — GBM

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