Retinoic acid receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Retinoic acid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY6, TTC36, and CLEC2D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinoic acid receptor signaling pathway activity versus P2RY6 in BLOOD_Leukemia (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	P2RY6 →	-1.641	-0.204	<.001	.001	3	5
LUNG_SCLC	TTC36 →	+0.556	+0.115	.005	.006	3	4
PANCREAS	CLEC2D →	+1.393	+0.225	.001	<.001	3	4
LUNG_NSCLC_LUAD	DYNC1LI1 →	+0.542	+0.188	.002	.002	3	4
CNS	DNAJC5 →	-0.537	-0.203	<.001	<.001	3	4
CNS	DSTN →	-0.990	-0.187	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048384 vs P2RY6 — BLOOD_Leukemia

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