Mesendoderm development

Across TCGA patient cohorts, RNA activity of the Mesendoderm development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFL6, SLC22A23, and SH3RF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesendoderm development activity versus EGFL6 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EGFL6 →	+0.744	+0.198	<.001	<.001	3	3
PDAC	SLC22A23 →	-0.382	-0.252	.001	.006	3	3
GBM	SH3RF1 →	-0.362	-0.349	<.001	.003	3	3
OV	ENPP5 →	+0.491	+0.099	.004	.004	3	3
COAD	SOWAHB →	-0.634	-0.480	<.001	.001	3	3
CCRCC	RPL21P5 →	-0.310	-0.315	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048382 vs EGFL6 — BRCA

Explore this scatter interactively →