Lateral mesoderm development

Across TCGA patient cohorts, RNA activity of the Lateral mesoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSTL1, SASH3, and DOCK10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lateral mesoderm development activity versus FSTL1 in CCRCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FSTL1 →	+0.542	+0.031	<.001	.001	3	7
OV	SASH3 →	-0.505	-0.061	.007	.002	3	5
LSCC	DOCK10 →	-0.306	-0.065	.002	.001	3	5
OV	DOK2 →	-0.540	-0.078	.001	<.001	3	5
LSCC	GBP1 →	-0.568	-0.087	<.001	<.001	3	5
HNSC	PSMB9 →	-0.406	-0.071	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048368 vs FSTL1 — CCRCC

Explore this scatter interactively →