Lateral mesoderm development

Across TCGA patient cohorts, RNA activity of the Lateral mesoderm development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNLL1P2, KRT18P17, and UBE2NL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lateral mesoderm development activity versus DYNLL1P2 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DYNLL1P2 →	+1.564	+0.545	<.001	<.001	3	4
BRCA	KRT18P17 →	+1.122	+0.525	<.001	.001	3	3
BRCA	UBE2NL →	+0.903	+0.592	<.001	.002	3	3
BRCA	CTBP2P4 →	+0.989	+0.743	<.001	<.001	3	3
BRCA	SH2D3A →	+0.467	+0.548	.005	.001	2	4
BRCA	EML3 →	+0.424	+0.418	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048368 vs DYNLL1P2 — BRCA

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