Lateral mesoderm development

Across TCGA patient cohorts, RNA activity of the Lateral mesoderm development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3RF1_S323, NES_S1577, and YAP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lateral mesoderm development activity versus SH3RF1_S323 in LSCC (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SH3RF1_S323 →	-0.877	-0.407	<.001	.001	3	3
BRCA	NES_S1577 →	+0.569	+0.693	.002	<.001	3	3
HNSC	YAP1 →	+0.535	+0.196	.001	<.001	3	3
HNSC	YAP1_S340 →	+0.652	+0.154	<.001	<.001	3	3
OV	RFX7_S1128 →	+1.903	+1.376	.004	.003	3	2
OV	SEC16A_S2022 →	+1.247	+0.654	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048368 vs SH3RF1_S323 — LSCC

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