Paraxial mesoderm morphogenesis

pathway activity — cross-omics
GO:0048340Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Paraxial mesoderm morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGHV1OR16-4, CACNG4, and RPL7P10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCIGHV1OR16-4 →-0.269-0.512.002.00734
BRCACACNG4 →-1.884-0.522<.001<.00134
LUADRPL7P10 →+0.214+0.512.001.00633
CCRCCGPAT3 →+0.713+0.479<.001.00233
CCRCCDSG2 →+0.661+0.507.005.00333
OVCRACDL →-0.544-0.633<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration