Paraxial mesoderm development

Across TCGA patient cohorts, RNA activity of the Paraxial mesoderm development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK18, YAP1, and GLYATL1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Paraxial mesoderm development activity versus CDK18 in PDAC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CDK18 →	+0.260	+0.220	.006	.008	3	4
PDAC	YAP1 →	+0.300	+0.329	.007	.006	2	5
BRCA	GLYATL1B →	-0.934	-0.724	.006	<.001	3	3
LUAD	EFNB1 →	+0.648	+0.190	<.001	.008	3	3
GBM	SYNGR3 →	-1.018	-0.311	<.001	.001	3	3
PDAC	CDC37L1 →	+0.253	+0.286	.002	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048339 vs CDK18 — PDAC

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