Paraxial mesoderm development

Across TCGA cell cohorts, RNA activity of the Paraxial mesoderm development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGL, MGA, and HDLBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGL grouped by Paraxial mesoderm development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AGL →	+0.697	+0.836	.007	.008	3	4
BLOOD_Leukemia	MGA →	+1.163	+1.320	<.001	.006	3	4
KIDNEY	HDLBP →	+0.778	+1.120	.002	.001	3	4
PANCREAS	KIF1B →	+0.745	+1.351	.006	.005	3	4
KIDNEY	QRICH1 →	+0.800	+1.237	.005	.003	2	5
LIVER	DCTN1 →	+0.579	+1.276	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGL by Paraxial mesoderm development activity — OESOPHAGUS

Explore this box plot interactively →