Lung alveolus development

Across TCGA patient cohorts, RNA activity of the Lung alveolus development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SON, C1R, and IGFBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung alveolus development activity versus SON in GBM (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SON →	-0.204	-0.054	.002	<.001	3	7
OV	C1R →	+0.566	+0.039	<.001	<.001	3	7
OV	IGFBP7 →	+0.742	+0.044	.001	.001	2	8
OV	LAMB1 →	+0.409	+0.038	<.001	<.001	3	7
OV	PLS3 →	+0.659	+0.046	<.001	<.001	3	7
OV	SNRNP70 →	-0.728	-0.047	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048286 vs SON — GBM

Explore this scatter interactively →