Lung alveolus development

Across TCGA pan-cancer cohorts, RNA activity of the Lung alveolus development pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 49 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Lung alveolus development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and KIRC, show the opposite pattern, with higher activity associated with better survival.

HNSC, LIHC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.430	0.207	<.001	121	view →
LIHC	OS	Median	All	0.402	0.586	<.001	44	view →
KIRC	OS	Median	All	0.904	0.848	.005	21	view →
STAD	DFS	Tertile	All	0.427	0.638	.019	17	view →
THCA	OS	Median	II,III,IV	0.907	0.980	.011	17	view →
COAD	DFS	Median	All	0.609	0.732	.007	14	view →
ACC	DFS	Tertile	All	0.171	0.554	.015	14	view →
KIRP	DFS	Quartile	All	0.746	0.909	.005	13	view →
READ	DFS	Quartile	IV	0.055	0.671	.002	12	view →
LUSC	DFS	Tertile	III,IV	0.376	0.904	.018	11	view →
CESC	DFS	Tertile	All	0.654	0.791	.036	10	view →
PCPG	DFS	Median	All	0.968	0.829	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0048286–HNSC (DFS)

Open the HNSC breakdown →