Lung alveolus development

Across TCGA patient cohorts, RNA activity of the Lung alveolus development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANGPTL2, ERRFI1, and ADM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung alveolus development activity versus ANGPTL2 in GBM (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANGPTL2 →	+0.418	+0.526	.001	<.001	3	5
PDAC	ERRFI1 →	+0.598	+0.514	.002	.003	3	4
LSCC	ADM →	+1.009	+0.681	.002	.002	3	4
PDAC	LINC01356 →	-0.083	-0.492	.007	.008	3	4
OV	CCN4 →	+0.819	+0.615	.003	.004	3	4
OV	CALD1 →	+0.972	+0.808	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048286 vs ANGPTL2 — GBM

Explore this scatter interactively →