Lung alveolus development

Across TCGA cell cohorts, RNA activity of the Lung alveolus development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL16, STS, and ARV1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL16 grouped by Lung alveolus development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARL16 →	+0.675	+1.219	.001	.001	3	4
BLOOD_Myeloma	STS →	-2.666	-1.222	.002	<.001	3	4
LARGE_INTESTINE	ARV1 →	+0.853	+1.139	.003	<.001	2	5
LIVER	HECTD2 →	+1.028	+1.732	.003	<.001	3	4
PANCREAS	PLSCR3 →	-1.102	-0.927	.007	.008	3	4
PANCREAS	HIKESHI →	+0.512	+0.862	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL16 by Lung alveolus development activity — LUNG_SCLC

Explore this box plot interactively →