Lung alveolus development

Across TCGA cell cohorts, RNA activity of the Lung alveolus development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBC, CDH24, and PPP1R18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lung alveolus development activity versus UBC in LUNG_NSCLC_LUAD (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UBC →	-0.631	-0.354	.001	.002	3	4
CNS	CDH24 →	-0.955	-1.149	.002	.007	3	4
LUNG_NSCLC_LUAD	PPP1R18 →	-1.283	-0.287	<.001	.004	3	3
BLOOD_Lymphoma	SEC23A →	-1.259	-0.312	.001	<.001	3	3
LUNG_SCLC	SIPA1L3 →	+1.203	+1.097	.008	.008	3	3
LUNG_SCLC	COX6A1 →	+0.456	+1.142	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048286 vs UBC — LUNG_NSCLC_LUAD

Explore this scatter interactively →