Organelle fusion

Across TCGA patient cohorts, RNA activity of the Organelle fusion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM220, BANK1, and HMGA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle fusion activity versus TMEM220 in OV (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TMEM220 →	-0.455	-0.105	.005	.009	3	3
HNSC	BANK1 →	-0.833	-0.194	.007	<.001	2	4
UCEC	HMGA1 →	+0.843	+0.291	.006	.006	3	3
UCEC	ATP6V1C2 →	+2.360	+0.378	.001	.005	3	3
LUAD	RPL13AP20 →	+0.851	+0.170	.003	.001	3	3
PDAC	NAMPT →	+0.459	+0.150	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048284 vs TMEM220 — OV

Explore this scatter interactively →