Vesicle fusion with Golgi apparatus

Across TCGA patient cohorts, RNA activity of the Vesicle fusion with Golgi apparatus pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RGS3_S1007, FAM160B1, and CCDC186, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle fusion with Golgi apparatus activity versus RGS3_S1007 in PDAC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RGS3_S1007 →	+0.524	+0.039	<.001	<.001	3	5
OV	FAM160B1 →	+0.244	+0.031	.001	.004	3	5
LUAD	CCDC186 →	+0.265	+0.046	<.001	<.001	3	5
CCRCC	JCHAIN →	+0.448	+0.026	.002	.005	3	4
BRCA	ACSL5 →	+0.428	+0.026	.004	.001	2	5
PDAC	SIPA1L2_S1499 →	+0.486	+0.037	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048280 vs RGS3_S1007 — PDAC

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