Vesicle fusion with Golgi apparatus

Across TCGA patient cohorts, RNA activity of the Vesicle fusion with Golgi apparatus pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAP4, RAPGEF5, and PLEKHG3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle fusion with Golgi apparatus activity versus PGAP4 in LSCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PGAP4 →	-0.968	-0.198	.001	.003	3	5
GBM	RAPGEF5 →	-0.750	-0.145	.001	.008	3	4
LSCC	PLEKHG3 →	-0.593	-0.230	<.001	<.001	3	4
CCRCC	GPR17 →	-0.814	-0.262	.001	.001	3	4
CCRCC	PURG →	-0.327	-0.240	<.001	<.001	3	4
CCRCC	CCDC71 →	-0.236	-0.251	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048280 vs PGAP4 — LSCC

Explore this scatter interactively →